Alcohols and polyols

Organic compounds containing one or more hydroxyl functional groups bonded to a carbon atom; hydroxyls consist of an oxygen atom bonded to a hydrogen atom. Alcohols exist in chain, or as closed rings. Polyols contain two or more hydroxyl groups.

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1,411 – 1,425 of 4,995 results

1,411

Medchemexpress LLC Prasugrel hydrochloride | 389574-19-0 | C20H21ClFNO3S | 500 MG

Prasugrel hydrochloride (PCR 4099 hydrochloride) is a thienopyridine and a proagent that inhibits platelet function. It is an orally active and potent P2Y12 receptor antagonist, which works by inhibiting ADP-induced platelet aggregation. In rat platelets, the active metabolite of Prasugrel hydrochloride inhibits in vitro platelet aggregation induced by adenosine ADP (10μM) with an IC50 value of 1.8 μM.

Exhibits faster and significantly more potent antiplatelet effects in vivo compared to Clopidogrel.
Requires in vivo metabolic processing as an inactive prodrug to generate its active antiplatelet metabolite.
Rapidly absorbed from the gut following oral administration.
Achieves maximum plasma levels of active metabolite within 1 hour.
Leads to effective, maximum inhibition of platelet aggregation within 1-2 hours.

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1,412

Medchemexpress LLC Alpelisib | 1217486-61-7 | C19H23ClF3N5O2S | 5 MG

Alpelisib hydrochloride is a potent, orally active, and selective PI3Kα inhibitor with IC50s of 5 nM for p110α. It exhibits antineoplastic activity and potently inhibits Akt phosphorylation in cells transformed with PI3Kα.

Potently inhibits PIK3CA somatic mutations (H1047R, E545K; IC50s~4 nM).
Significantly reduces Akt phosphorylation in cells transformed with PI3Kα (IC50=74±15 nM).
Inhibits cell growth of osteosarcoma cell lines.
Induces G0/G1 phase cell cycle arrest in human and murine osteosarcoma cells.
Reduces tumor volumes and deposition of ectopic bone matrix in animal models.
Store powder at -20°C for 3 years or 4°C for 2 years.
Store in solvent at -80°C for 2 years or -20°C for 1 year.
Shipping can occur at room temperature if duration is less than 2 weeks.

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1,413

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG

EPZ004777 hydrochloride is an effective and selective DOT1L inhibitor with an IC50 of 0.4 nM. This compound reduces levels of H3K79me2 and H3K79me1, leading to a significant down-regulation of HOXA9 and MEIS1 expression. It selectively inhibits the proliferation of MLL rearrangement cells and promotes the differentiation and subsequent apoptosis of leukemia cells, making it suitable for leukemia research.

Effective and selective DOT1L inhibitor
Reduces H3K79me2 and H3K79me1 levels
Down-regulates HOXA9 and MEIS1 expression
Selectively inhibits MLL rearrangement cell proliferation
Promotes differentiation and apoptosis of leukemia cells
Potent DOT1L enzyme activity inhibition (IC50 of 400±100 pM)
Demonstrates selectivity over other histone methyltransferases (HMTs)

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1,414

Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 5 MG

Dopexamine hydrochloride is a β2 adrenergic receptor agonist and a dopamine analogue with agonist activity at β2 and dopaminergic receptors. It can attenuate systemic inflammatory response, reduce tissue leukocyte infiltration, and protect against organ injury at doses that do not alter global hemodynamics or regional microvascular flow. It also reduces the systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress, without substantially changing systemic hemodynamics.

β2 adrenergic receptor agonist
Dopamine analogue with agonist activity at β2 and dopaminergic receptors
Attenuates systemic inflammatory response
Reduces tissue leukocyte infiltration
Protects against organ injury
Reduces systemic inflammatory response to endotoxin, including cytokine release, endothelial adhesion molecules, and oxidative stress

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1,415

Medchemexpress LLC Bambuterol hydrochloride | 81732-46-9 | MFCD03427293 | 99.9% | 403.90 | 100 MG

Bambuterol hydrochloride, also known as (±)-Bambuterol hydrochloride, is a long-acting beta-adrenoceptor agonist (LABA). It is primarily utilized in the treatment of asthma and functions as a proagent of terbutaline. Intended for research use only, this product is contraindicated in pregnancy and for individuals with severely impaired liver function, requiring dose adjustments for renal impairment.

Used in the treatment of asthma.
Functions as a proagent of terbutaline.
Intended for research use only.
Purity of 99.9%.
Available in solid form.

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1,416

Medchemexpress LLC Defactinib hydrochloride | 1073160-26-5 | 99.4% | 50 MG

Defactinib hydrochloride is the hydrochloride salt of defactinib (VS-6063; PF-04554878), a small-molecule focal adhesion kinase (FAK) inhibitor used in research to study FAK signaling, tumor cell motility, and antineoplastic and antiangiogenic mechanisms.

Inhibits FAK phosphorylation at Tyr397 in a time- and dose-dependent manner.
Hydrochloride salt form, off-white powder suitable for research use.
Molecular formula C20H22ClF3N8O3S; molecular weight 546.95 g/mol.
Reported purity 99.35% with available certificate of analysis.
Available in multiple pack sizes, including 50 mg.
Supporting documents available: data sheet, COA, and SDS.

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1,417

Medchemexpress LLC Serotonin hydrochloride | 153-98-0 | 99.97% | 1 ML

Serotonin hydrochloride (5-Hydroxytryptamine hydrochloride) is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. It possesses blood-brain barrier permeability and also acts as a catechol O-methyltransferase (COMT) inhibitor.

Functions as a monoamine neurotransmitter.
Acts as an endogenous 5-HT receptor agonist.
Exhibits blood-brain barrier permeability.
Inhibits catechol O-methyltransferase (COMT) with a Ki of 44 μM.
Decreases COMT reaction velocity at 100 μM concentration.
Offers high purity (99.97%).
Available as solid or solution in DMSO.

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1,418

Medchemexpress LLC Glafenine (hydrochloride) | 65513-72-6 | 10 MM 1 ML

Glafenine (hydrochloride) | 65513-72-6 | 10 MM 1 ML

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1,419

Medchemexpress LLC Etifoxine hydrochloride | 56776-32-0 | 99.8% | 337.24 | 10 MM 1 ML

Etifoxine hydrochloride is a non-benzodiazepine GABAergic compound. It acts as a positive allosteric modulator of α1β2γ2 and α1β3γ2 subunit-containing GABAA receptors. It has demonstrated anxiolytic and anticonvulsant properties in rodents.

Acts as a positive allosteric modulator of GABAA receptors.
Demonstrates anxiolytic properties.
Demonstrates anticonvulsant properties.

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1,420

Medchemexpress LLC SRI-011381 hydrochloride | 2070014-88-7 | 99.6% | 365.94 | C20H32ClN3O | 200 MG

SRI-011381 hydrochloride is an orally active TGF-β signaling agonist reported to exhibit neuroprotective effects in vitro and in vivo. It is supplied as a solid or as a DMSO solution for research use and is provided at high chemical purity.

Orally active TGF-β signaling agonist.
Promotes proliferation of mouse lung fibroblasts in vitro.
Increases TGF-β1, NALP3, collagen-1, and α-SMA expression.
Demonstrates neuroprotective effects in animal models, reducing inflammation and neuron loss.
Available as a solid and as 10 mM solution in DMSO in multiple package sizes.
High purity suitable for research applications.

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1,421

Medchemexpress LLC CHK1-IN-4 hydrochlo | 1MG

CHK1-IN-4 hydrochlo | 1MG

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1,422

Medchemexpress LLC SSR180711 hydrochloride | 446031-79-4 | 99.90% | 361.66 | 1 ML

SSR180711 hydrochloride is an orally active, selective, and reversible α7 acetylcholine nicotinic receptor (n-AChRs) partial agonist. It can act on rat α7 n-AChR (Ki=22 nM; IC50=30 nM) and human α7 n-AChR (Ki=14 nM; IC50=18 nM). This compound increases glutamatergic neurotransmission, ACh release, and long-term potentiation (LTP) in the hippocampus.

Acts on rat α7 n-AChR (Ki=22 nM; IC50=30 nM) and human α7 n-AChR (Ki=14 nM; IC50=18 nM).
Increases glutamatergic neurotransmission, ACh release, and long-term potentiation (LTP) in the hippocampus.
Selective for the α7 receptor subtype compared to α4β2, α3β2, α3β4, and α1β1γδ human n-AChR subtypes.
Rapidly penetrates into the brain (ID50=8 mg/kg; p.o.).
Dose-dependently inhibits specific [3H]α-BTX binding in the mouse brain.
Dose-dependently increases extracellular acetylcholine (ACh) levels in the hippocampus and prefrontal cortex of freely moving rats.

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1,423

Medchemexpress LLC N,N-Dimethyl-3-(5-(2-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-indol-1-yl)propan-1-amine hydrochloride | 97.0% | C20H24ClN5O2S | 50 MG

DC-BPi-11 hydrochloride is an inhibitor of bromodomain PHD finger transcription factor (BPTF), with an IC50 value of 698 nM. It demonstrates remarkable inhibition against leukemia cell proliferation and is suitable for laboratory research. The compound shows minimal effects on normal cells.

Inhibits BPTF with an IC50 value of 698 nM
Shows remarkable inhibition against leukemia cell proliferation
Inhibits BPTF in human leukemia MV-4-11 cells with an EC50 value of 120 nM
Significantly inhibits the proliferation of human leukemia MV-4-11 cells (IC50=0.89 μM)
Decreases downstream oncogene expression at concentrations between 2.5-20 μM
Dose-dependently decreases c-Myc protein level
Shows minimal effects on normal cells, indicating its safety

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1,424

Medchemexpress LLC 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy- | 485-47-2 | 100.0 % | 100 G

Ninhydrin is a chromogenic analytical probe used for the quantification of amino acids and proteins. It reacts with primary and secondary amines, producing a blue or purple reaction product, diketohydrindylidene-diketohydrindamine. It is utilized in the amino acid analysis of proteins; most amino acids, excluding proline, can be hydrolyzed and react with ninhydrin, after which they are colorimetrically quantified following chromatographic separation.

Chromogenic analytical probe.
Reacts with primary and secondary amines.
Solid appearance, white to light yellow color.
Quantification of amino acids and proteins.
Useful in amino acid analysis of proteins.

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1,425

Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 1 G

Eperisone hydrochloride is an orally active antispastic agent with a vasodilator effect. It is used for the research of muscle stiffness and pain. This compound is a potent and selective P2X7 receptor antagonist, also exhibiting antagonism for human P2X3. It works by relaxing both skeletal muscles and vascular smooth muscles, demonstrating several beneficial effects.

Reduces myotonia.
Improves circulation.
Suppresses the pain reflex.
Preferentially suppresses lung fibroblast activity.
Suppresses bleomycin-dependent pulmonary fibrosis.
Not toxic to alveolar epithelial cells in vitro.

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Alcohols and polyols

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Medchemexpress LLC Prasugrel hydrochloride | 389574-19-0 | C20H21ClFNO3S | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Alpelisib | 1217486-61-7 | C19H23ClF3N5O2S | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC EPZ004777 hydrochloride | 1380316-03-9 | C28H42ClN7O4 | 25 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Dopexamine hydrochloride | 86484-91-5 | 429.42 | 5 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Bambuterol hydrochloride | 81732-46-9 | MFCD03427293 | 99.9% | 403.90 | 100 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Defactinib hydrochloride | 1073160-26-5 | 99.4% | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Serotonin hydrochloride | 153-98-0 | 99.97% | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Glafenine (hydrochloride) | 65513-72-6 | 10 MM 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Etifoxine hydrochloride | 56776-32-0 | 99.8% | 337.24 | 10 MM 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SRI-011381 hydrochloride | 2070014-88-7 | 99.6% | 365.94 | C20H32ClN3O | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC CHK1-IN-4 hydrochlo | 1MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC SSR180711 hydrochloride | 446031-79-4 | 99.90% | 361.66 | 1 ML Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC N,N-Dimethyl-3-(5-(2-(methylsulfonyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-indol-1-yl)propan-1-amine hydrochloride | 97.0% | C20H24ClN5O2S | 50 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 1H-Indene-1,3(2H)-dione, 2,2-dihydroxy- | 485-47-2 | 100.0 % | 100 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Eperisone (hydrochloride) | 56839-43-1 | 99.95% | 1 G Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More